The Met Gold Rapid Screen Test Cassette is chromatographic for the detection methamphetamine in urine, methamphetamine compete with drug antigen immobilized on a porous membrane support for limited antibody sites. Labeled antibody mixes with sample specimen and binds to the free drug presented in sample forming an antibody-antigen complex. This complex prevents the formation of red color bands in the test zone immobilized antigen conjugate when the drug is presented in the sample urine above the detection levels (1000ng/ml for Methamphetamine). Unbound conjugate binds to the reagent in the control zone and produces a red color band, demonstrating that the reagents and device are functioning correctly. A negative specimen produces two distinct color bands, one for the control in the “C” zone and one Methamphetamine in the “T” zone.